Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells

DOI Web Site PubMed 被引用文献3件 参考文献50件
  • Takaya Ichikawa
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Yusuke Okuno
    Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan
  • Yoshitaka Sato
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Fumi Goshima
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Hironori Yoshiyama
    Department of Microbiology, Shimane University Faculty of Medicine, Izumo, Japan
  • Teru Kanda
    Division of Microbiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
  • Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Takayuki Murata
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Blossom Damania
    editor

説明

<jats:p>The life cycle of EBV is regulated by epigenetic modifications, such as CpG methylation and histone modifications. Here, we found that the expression of EZH2, which encodes a histone H3K27 methyltransferase, was induced by EBV infection; therefore, we generated EZH2-KO cells to investigate the role of EZH2 in EBV-infected Akata B cells. Disruption of EZH2 resulted in increased expression of EBV genes during the lytic phase and, therefore, efficient viral replication and progeny production. Our results shed light on the mechanisms underlying reactivation from an epigenetic point of view and further suggest a role for EZH2 as a form of innate immunity that restricts viral replication in infected cells.</jats:p>

収録刊行物

  • mSphere

    mSphere 3 (6), e00478-18-, 2018-12-26

    American Society for Microbiology

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