Traveled Distance Is a Sensitive and Accurate Marker of Motor Dysfunction in a Mouse Model of Multiple Sclerosis
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- Takako Takemiya
- Medical Research Institute, Tokyo Women’s Medical University, Tokyo 162-8666, Japan
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- Chisen Takeuchi
- Kita Medical and Rehabilitation Center for Disabled, Tokyo 114-0033, Japan
書誌事項
- 公開日
- 2013-12-10
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.1155/2013/170316
- 公開者
- Wiley
説明
<jats:p>Multiple sclerosis (MS) is a common central nervous system disease associated with progressive physical impairment. To study the mechanisms of the disease, we used experimental autoimmune encephalomyelitis (EAE), an animal model of MS. EAE is induced by myelin oligodendrocyte <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mtext>glycoprotein</mml:mtext></mml:mrow><mml:mrow><mml:mn mathvariant="normal">3</mml:mn><mml:mn mathvariant="normal">5</mml:mn><mml:mtext>–</mml:mtext><mml:mn mathvariant="normal">5</mml:mn><mml:mn mathvariant="normal">5</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> peptide, and the severity of paralysis in the disease is generally measured using the EAE score. Here, we compared EAE scores and traveled distance using the open-field test for an assessment of EAE progression. EAE scores were obtained with a 6-step observational scoring system for paralysis, and the traveled distance was obtained by automatic trajectory analysis of natural exploratory behaviors detected by a computer. The traveled distance of the EAE mice started to decrease significantly at day 7 of the EAE process, when the EAE score still did not reflect a change. Moreover, in the relationship between the traveled distance and paralysis as measured by the EAE score after day 14, there was a high coefficient of determination between the distance and the score. The results suggest that traveled distance is a sensitive marker of motor dysfunction in the early phases of EAE progression and that it reflects the degree of motor dysfunction after the onset of paralysis in EAE.</jats:p>
収録刊行物
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- ISRN Neuroscience
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ISRN Neuroscience 2013 1-4, 2013-12-10
Wiley
