Helical Structures of Cyclopentene-based α,α-Disubstituted α-Amino Acid Homopeptides
書誌事項
- 公開日
- 2018-12-19
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by-nc/4.0/
- DOI
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- 10.2533/chimia.2018.848
- 公開者
- Swiss Chemical Society
この論文をさがす
説明
<jats:p>The cyclopentene-based α,α-disubstituted α-amino acid Ac5c= and its homopeptides, up to nonapeptides, were synthesized. The side-chain cyclopentene was expected to become symmetric, the Cα-carbon to be puckered, and other Cβ, Cβ', Cγ, Cγ'-carbons to be coplanar. As expected, side-chain cyclopentene conformations became symmetric and Cα-carbons were puckered. Conformational studies using FT-IR absorption, 1H NMR spectra, and X-ray crystallographic analyses revealed that Ac5c= homopeptides did not form a planar conformation, but assumed a 310-helical structure, similar to cyclopentane-based α,α-disubstituted α-amino acid homopeptides.</jats:p>
収録刊行物
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- CHIMIA
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CHIMIA 72 (12), 848-, 2018-12-19
Swiss Chemical Society
