The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy
書誌事項
- 公開日
- 2014-08-29
- 資源種別
- journal article
- DOI
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- 10.3389/fnagi.2014.00230
- 公開者
- Frontiers Media SA
説明
Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, atrogin-1, myostatin, etc.) seem to modulate protein synthesis and degradation or transcription of muscle-specific genes during both sarcopenia and muscular dystrophy. This review provides an overview of the adaptive changes in several regulators of muscle mass in both sarcopenia and muscular dystrophy.
収録刊行物
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- Frontiers in Aging Neuroscience
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Frontiers in Aging Neuroscience 6 230-, 2014-08-29
Frontiers Media SA
