Regenerating Gene Protein as a Novel Autoantigen in the Pathogenesis of Sjögren’s Syndrome

DOI Web Site 参考文献93件 オープンアクセス
  • Takashi Fujimoto
    The Center for Rheumatic Diseases, Nara Medical University Hospital, 840 Shijo-cho, Kashihara 634-8522, Japan
  • Kiyomi Yoshimoto
    Department of General Medicine, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan
  • Takanori Fujimura
    The Center for Rheumatic Diseases, Nara Medical University Hospital, 840 Shijo-cho, Kashihara 634-8522, Japan
  • Maiko Takeda
    Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, Japan
  • Akiyo Yamauchi
    Department of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Japan
  • Asako Itaya-Hironaka
    Department of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Japan
  • Shin Takasawa
    Department of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Japan

書誌事項

公開日
2015-12-07
資源種別
journal article
権利情報
  • https://creativecommons.org/licenses/by/4.0/
DOI
  • 10.3390/antib4040409
公開者
MDPI AG

説明

<jats:p>Sjögren’s syndrome, an autoimmune disease characterized by exocrine gland dysfunction leading to dry mouth and dry eye diseases, is typified by lymphoplasmacytic infiltrations and a progressive destruction of the salivary and lacrimal glands. Despite an ever-increasing focus on identifying the underlying etiology of Sjögren’s syndrome, the factors that initiate this autoimmune disease and the mechanisms that cause the subsequent exocrine gland dysfunction remain a mystery. The original explanatory concept for the pathogenesis of Sjögren’s syndrome proposed a specific, self-perpetuating, immune-mediated loss of acinar and ductal cells as the principal cause of salivary gland dysfunction. We highlight the possible involvement of regenerating gene (Reg) in the regeneration and destruction of salivary gland acinar and ductal cells in Sjögren’s syndrome. The Reg gene was originally isolated as a gene specifically overexpressed in regenerating pancreatic islets and constitutes a growth factor family (Reg family). We describe how salivary gland dysfunction is initiated and maintained and how it can be regenerated or progressed, mediated by the Reg gene, Reg protein, and anti-REG autoantibodies in Sjögren’s syndrome.</jats:p>

収録刊行物

  • Antibodies

    Antibodies 4 (4), 409-425, 2015-12-07

    MDPI AG

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