In vivo evidence that acyl coenzyme A regulates DNA binding by the Escherichia coli FadR global transcription factor
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- J E Cronan
- Department of Microbiology, University of Illinois, Urbana 61801, USA. John_Cronan@qms1.life.uiuc.edu
抄録
<jats:p>In vitro experiments point to fatty acyl coenzymes A (acyl-CoAs) rather than unesterified fatty acids as the small-molecule ligands regulating DNA binding by the FadR protein of Escherichia coli. To provide an in vivo test of this specificity, unesterified fatty acids were generated within the cellular cytosol. These fatty acids were found to be efficient modulators of FadR action only when the acids could be converted to acyl-CoAs.</jats:p>
収録刊行物
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- Journal of Bacteriology
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Journal of Bacteriology 179 (5), 1819-1823, 1997-03
American Society for Microbiology