Investigating changes in the gas-phase conformation of Antithrombin III upon binding of Arixtra using traveling wave ion mobility spectrometry (TWIMS)
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- Yuejie Zhao
- University of Georgia
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- Arunima Singh
- University of Georgia
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- Lingyun Li
- Rensselaer Polytechnic Institute
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- Robert J. Linhardt
- Rensselaer Polytechnic Institute
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- Yongmei Xu
- University of North Carolina
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- Jian Liu
- University of North Carolina
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- Robert J. Woods
- University of Georgia
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- I. Jonathan Amster
- University of Georgia
説明
<p>We validate the utility of ion mobility to measure protein conformational changes induced by the binding of glycosaminoglycan ligands.</p>
収録刊行物
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- The Analyst
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The Analyst 140 (20), 6980-6989, 2015
Royal Society of Chemistry (RSC)