Synthesis and Antimalarial Activity of Cyclic Peroxides, 1,2,4,5,7-Pentoxocanes and 1,2,4,5-Tetroxanes
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- Hye-Sook Kim
- Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
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- Yasuharu Shibata
- Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
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- Yusuke Wataya
- Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
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- Kaoru Tsuchiya
- Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
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- Araki Masuyama
- Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
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- Masatomo Nojima
- Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, and Department of Materials Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
書誌事項
- 公開日
- 1999-06-29
- DOI
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- 10.1021/jm990014j
- 公開者
- American Chemical Society (ACS)
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説明
A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted.
収録刊行物
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- Journal of Medicinal Chemistry
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Journal of Medicinal Chemistry 42 (14), 2604-2609, 1999-06-29
American Chemical Society (ACS)
