Animal Model To Study Klebsiella pneumoniae Gastrointestinal Colonization and Host-to-Host Transmission

DOI Web Site 1 Citations
  • Taylor M. Young
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
  • Andrew S. Bray
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
  • Ravinder K. Nagpal
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
  • David L. Caudell
    Department of Pathology-Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
  • Hariom Yadav
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
  • M. Ammar Zafar
    Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
  • Denise Monack
    editor

Abstract

<jats:p> An important yet poorly understood facet of the life cycle of a successful pathogen is host-to-host transmission. Hospital-acquired infections (HAI) resulting from the transmission of drug-resistant pathogens affect hundreds of millions of patients worldwide. <jats:named-content content-type="genus-species">Klebsiella pneumoniae</jats:named-content> , a Gram-negative bacterium, is notorious for causing HAI, with many of these infections difficult to treat, as <jats:named-content content-type="genus-species">K. pneumoniae</jats:named-content> has become multidrug resistant. Epidemiological studies suggest that <jats:named-content content-type="genus-species">K. pneumoniae</jats:named-content> host-to-host transmission requires close contact and generally occurs through the fecal-oral route. </jats:p>

Journal

  • Infection and Immunity

    Infection and Immunity 88 (11), e00071-, 2020-10-19

    American Society for Microbiology

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