SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection
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- Laura Bashor
- Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;
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- Roderick B. Gagne
- Department of Pathobiology, Wildlife Futures Program, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA 19348;
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- Angela M. Bosco-Lauth
- Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
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- Richard A. Bowen
- Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523
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- Mark Stenglein
- Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;
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- Sue VandeWoude
- Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523;
書誌事項
- 公開日
- 2021-10-29
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1073/pnas.2105253118
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title> <jats:p>SARS-CoV-2 emerged because of viral spillover from animals to humans, and spillback to other animal species has been observed with accelerating frequency. Cross-species transmission generally results in the rapid adaptation of the virus to the new host, and repeated transmissions may hasten viral evolution and novel strain emergence. We report the surprisingly rapid selection of numerous SARS-CoV-2 variants in cell culture and following infection of nonhuman mammalian hosts, including dogs and cats. These molecular changes in SARS-CoV-2 provide insight into mechanisms of viral host adaptation, lay the groundwork for additional studies assessing dominant variant fitness and phenotype, and highlight the potential for human reinfection with new viral variants arising in species in close and frequent contact with humans.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 118 (44), e2105253118-, 2021-10-29
Proceedings of the National Academy of Sciences
