The association between trypsin‐like protease activity in the oral cavity and kidney function in Japanese workers
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- Masanori Iwasaki
- Dental Center for Regional Medical Survey Kyushu Dental University Kitakyushu Fukuoka Japan
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- Maki Inoue
- Dental Center for Regional Medical Survey Kyushu Dental University Kitakyushu Fukuoka Japan
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- Michihiko Usui
- Division of Periodontology Kyushu Dental University Kitakyushu Fukuoka Japan
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- Wataru Ariyoshi
- Division of Infections and Molecular Biology Kyushu Dental University Kitakyushu Fukuoka Japan
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- Keisuke Nakashima
- Division of Periodontology Kyushu Dental University Kitakyushu Fukuoka Japan
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- Yoshie Nagai‐Yoshioka
- Division of Infections and Molecular Biology Kyushu Dental University Kitakyushu Fukuoka Japan
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- Tatsuji Nishihara
- Dental Center for Regional Medical Survey Kyushu Dental University Kitakyushu Fukuoka Japan
書誌事項
- 公開日
- 2023-11-28
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/jcpe.13908
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>To evaluate the association between trypsin‐like protease (TLP) activity in the oral cavity as an indicator of periodontal health status and kidney function in Japanese workers.</jats:p></jats:sec><jats:sec><jats:title>Materials and Methods</jats:title><jats:p>This cross‐sectional study included 1117 Japanese workers (mean age = 43.8 years). Tongue‐swab TLP activity was quantified as <jats:italic>a</jats:italic>* value (the redness intensity of the matrix disc of the TLP activity assessment kit; a larger value indicates more intense enzymatic activity in the samples and poorer periodontal health status). Kidney function was assessed using the estimated glomerular filtration rate (eGFR; a lower value indicates poorer kidney function). We performed ordinal logistic regression analyses to assess the association of the <jats:italic>a</jats:italic>* value with three eGFR categories: ≥90, 60–89 and <60 mL/min/1.73 m<jats:sup>2</jats:sup>.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The prevalence for each eGFR category was as follows: ≥90 (31.6%), 60–89 (63.8%) and <60 mL/min/1.73 m<jats:sup>2</jats:sup> (4.6%). After adjusting for potential confounders, the <jats:italic>a</jats:italic>* value was found to be significantly associated with reduced kidney function. The multivariable‐adjusted odds ratio (95% confidence interval) for reduced kidney function was 1.12 (1.02–1.22) per unit increase in the <jats:italic>a</jats:italic>* value.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Higher TLP activity was associated with reduced kidney function in Japanese workers.</jats:p></jats:sec>
収録刊行物
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- Journal of Clinical Periodontology
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Journal of Clinical Periodontology 51 (3), 265-273, 2023-11-28
Wiley
