Seaweed consumption and the risk of prostate cancer: the Miyagi cohort study

DOI Web Site 参考文献20件
  • Koichi Matsumoto
    Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai
  • Yumi Sugawara
    Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai
  • Toshimasa Sone
    Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai
  • Seiki Kanemura
    Division of Cancer Epidemiology and Prevention, Miyagi Prefectural Cancer Research Center, Natori
  • Akira Fukao
    Miyagi Cancer Society, Sendai, Japan
  • Ichiro Tsuji
    Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai

書誌事項

公開日
2023-04-10
資源種別
journal article
DOI
  • 10.1097/cej.0000000000000801
公開者
Ovid Technologies (Wolters Kluwer Health)

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説明

<jats:p>Some laboratory studies have shown that fucoidan, which is contained in seaweed extract, has inhibitory effects on the invasion and angiogenesis of tumor cells; however, the association between seaweed consumption and prostate cancer incidence remains unclear. The purpose of the present study was to examine the association between seaweed consumption and the risk of prostate cancer incidence in the Japanese population. Data from 19 311 men in the Miyagi Cohort Study who were 40–64 years old at baseline in 1990 were examined. Seaweed consumption was assessed at baseline using a self-administered food frequency questionnaire. The participants were divided into three categories based on seaweed consumption at baseline. During 24.5 years of follow-up, we identified 815 incident cases of prostate cancer. Multivariate analysis showed that seaweed consumption was not associated with prostate cancer incidence. The multivariate hazard ratios and 95% confidence intervals for prostate cancer incidence in the highest tertile versus the other tertiles were 0.76 (0.60–0.96) and 0.78 (0.61–0.99) (<jats:italic toggle="yes">P</jats:italic>-trend = 0.15). Furthermore, the null association was independent of whether their clinical stage was localized or advanced. In this population-based prospective cohort study conducted in Japan, we found no significant association between seaweed consumption and the incidence of prostate cancer.</jats:p>

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