Creating and Transferring an Innervated, Vascularized Muscle Flap Made from an Elastic, Cellularized Tissue Construct Developed In Situ

DOI Web Site 被引用文献1件 参考文献89件 オープンアクセス
  • Hideyoshi Sato
    McGowan Institute for Regenerative Medicine University of Pittsburgh 450 Technology Dr. Pittsburgh PA 15219 USA
  • Keishi Kohyama
    McGowan Institute for Regenerative Medicine University of Pittsburgh 450 Technology Dr. Pittsburgh PA 15219 USA
  • Takafumi Uchibori
    McGowan Institute for Regenerative Medicine University of Pittsburgh 450 Technology Dr. Pittsburgh PA 15219 USA
  • Keisuke Takanari
    McGowan Institute for Regenerative Medicine University of Pittsburgh 450 Technology Dr. Pittsburgh PA 15219 USA
  • Johnny Huard
    Center for Regenerative Sports Medicine Steadman Philippon Research Institute 181 West Meadow Dr. Vail CO 81657 USA
  • Stephen F. Badylak
    McGowan Institute for Regenerative Medicine University of Pittsburgh 450 Technology Dr. Pittsburgh PA 15219 USA
  • Antonio D'Amore
    McGowan Institute for Regenerative Medicine University of Pittsburgh 450 Technology Dr. Pittsburgh PA 15219 USA
  • William R. Wagner
    McGowan Institute for Regenerative Medicine University of Pittsburgh 450 Technology Dr. Pittsburgh PA 15219 USA

書誌事項

公開日
2023-08-04
資源種別
journal article
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/adhm.202301335
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Reanimating facial structures following paralysis and muscle loss is a surgical objective that would benefit from improved options for harvesting appropriately sized muscle flaps. The objective of this study is to apply electrohydrodynamic processing to generate a cellularized, elastic, biocomposite scaffold that could develop and mature as muscle in a prepared donor site in vivo, and then be transferred as a thin muscle flap with a vascular and neural pedicle. First, an effective extracellular matrix (ECM) gel type is selected for the biocomposite scaffold from three types of ECM combined with poly(ester urethane)urea microfibers and evaluated in rat abdominal wall defects. Next, two types of precursor cells (muscle‐derived and adipose‐derived) are compared in constructs placed in rat hind limb defects for muscle regeneration capacity. Finally, with a construct made from dermal ECM and muscle‐derived stem cells, protoflaps are implanted in one hindlimb for development and then microsurgically transferred as a free flap to the contralateral limb where stimulated muscle function is confirmed. This construct generation and in vivo incubation procedure may allow the generation of small‐scale muscle flaps appropriate for transfer to the face, offering a new strategy for facial reanimation.</jats:p>

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