Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease
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- Yozo Mitsui
- Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan
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- Fumito Yamabe
- Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan
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- Shunsuke Hori
- Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan
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- Masato Uetani
- Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan
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- Hideyuki Kobayashi
- Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan
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- Koichi Nagao
- Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan
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- Koichi Nakajima
- Department of Urology, Toho University Faculty of Medicine, Tokyo 143-8540, Japan
書誌事項
- 公開日
- 2023-06-14
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/ijms241210133
- 10.20944/preprints202304.1238.v1
- 公開者
- MDPI AG
説明
<jats:p>Peyronie’s disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, research into understanding of the detailed mechanisms and risk factors involved in the development of PD has been increasing. In this review, the pathological mechanisms and several closely related signaling pathways, including TGF-β, WNT/β-catenin, Hedgehog, YAP/TAZ, MAPK, ROCK, and PI3K/AKT, are described. Findings regarding cross-talk among these pathways are then discussed to elucidate the complicated cascade behind tunica albuginea fibrosis. Finally, various risk factors including the genes involved in the development of PD are presented and their association with the disease summarized. The purpose of this review is to provide a better understanding regarding the involvement of risk factors in the molecular mechanisms associated with PD pathogenesis, as well as to provide insight into disease prevention and novel therapeutic interventions.</jats:p>
収録刊行物
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- International Journal of Molecular Sciences
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International Journal of Molecular Sciences 24 (12), 10133-, 2023-06-14
MDPI AG
