“No-reflow” phenomenon in acute ischemic stroke

DOI Web Site Web Site 被引用文献3件
  • Yang Zhang
    Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
  • Miaowen Jiang
    Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China
  • Yuan Gao
    School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China
  • Wenbo Zhao
    Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
  • Chuanjie Wu
    Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
  • Chuanhui Li
    Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
  • Ming Li
    China-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
  • Di Wu
    China-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
  • Wu Wang
    Institute of Diagnostic and Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
  • Xunming Ji
    Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

書誌事項

公開日
2023-10-19
権利情報
  • https://journals.sagepub.com/page/policies/text-and-data-mining-license
DOI
  • 10.1177/0271678x231208476
公開者
SAGE Publications

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説明

<jats:p>Acute ischemic stroke (AIS) afflicts millions of individuals worldwide. Despite the advancements in thrombolysis and thrombectomy facilitating proximal large artery recanalization, the resultant distal hypoperfusion, referred to “no-reflow” phenomenon, often impedes the neurological function restoration in patients. Over half a century of scientific inquiry has validated the existence of cerebral “no-reflow” in both animal models and human subjects. Furthermore, the correlation between “no-reflow” and adverse clinical outcomes underscores the necessity to address this phenomenon as a pivotal strategy for enhancing AIS prognoses. The underlying mechanisms of “no-reflow” are multifaceted, encompassing the formation of microemboli, microvascular compression and contraction. Moreover, a myriad of complex mechanisms warrant further investigation. Insights gleaned from mechanistic exploration have prompted advancements in “no-reflow” treatment, including microthrombosis therapy, which has demonstrated clinical efficacy in improving patient prognoses. The stagnation in current “no-reflow” diagnostic methods imposes limitations on the timely application of combined therapy on “no-reflow” post-recanalization. This narrative review will traverse the historical journey of the “no-reflow” phenomenon, delve into its underpinnings in AIS, and elucidate potential therapeutic and diagnostic strategies. Our aim is to equip readers with a swift comprehension of the “no-reflow” phenomenon and highlight critical points for future research endeavors.</jats:p>

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