Danger‐associated molecular patterns (<scp>DAMPs</scp>) in acute lung injury

DOI Web Site Web Site 1 Citations
  • Leslie B Tolle
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine University of Michigan Medical Center Ann Arbor MI USA
  • Theodore J Standiford
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine University of Michigan Medical Center Ann Arbor MI USA

Description

<jats:title>Abstract</jats:title><jats:p>Danger‐associated molecular patterns (<jats:styled-content style="fixed-case">DAMPs</jats:styled-content>) are host‐derived molecules that can function to regulate the activation of pathogen recognition receptors (<jats:styled-content style="fixed-case">PRRs</jats:styled-content>). These molecules play a critical role in modulating the lung injury response. <jats:styled-content style="fixed-case">DAMPs</jats:styled-content> originate from multiple sources, including injured and dying cells, the extracellular matrix, or exist as immunomodulatory proteins within the airspace and interstitium. <jats:styled-content style="fixed-case">DAMPs</jats:styled-content> can function as either toll‐like receptor (<jats:styled-content style="fixed-case">TLR</jats:styled-content>) agonists or antagonists, and can modulate both <jats:styled-content style="fixed-case">TLR</jats:styled-content> and nod‐like receptor (<jats:styled-content style="fixed-case">NLR</jats:styled-content>) signalling cascades. Collectively, this diverse group of molecules may represent important therapeutic targets in the prevention and/or treatment of acute lung injury (<jats:styled-content style="fixed-case">ALI</jats:styled-content>) and its more severe form, acute respiratory distress syndrome (<jats:styled-content style="fixed-case">ARDS</jats:styled-content>).</jats:p>

Journal

Citations (1)*help

See more

Report a problem

Back to top