Danger‐associated molecular patterns (<scp>DAMPs</scp>) in acute lung injury
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- Leslie B Tolle
- Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine University of Michigan Medical Center Ann Arbor MI USA
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- Theodore J Standiford
- Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine University of Michigan Medical Center Ann Arbor MI USA
説明
<jats:title>Abstract</jats:title><jats:p>Danger‐associated molecular patterns (<jats:styled-content style="fixed-case">DAMPs</jats:styled-content>) are host‐derived molecules that can function to regulate the activation of pathogen recognition receptors (<jats:styled-content style="fixed-case">PRRs</jats:styled-content>). These molecules play a critical role in modulating the lung injury response. <jats:styled-content style="fixed-case">DAMPs</jats:styled-content> originate from multiple sources, including injured and dying cells, the extracellular matrix, or exist as immunomodulatory proteins within the airspace and interstitium. <jats:styled-content style="fixed-case">DAMPs</jats:styled-content> can function as either toll‐like receptor (<jats:styled-content style="fixed-case">TLR</jats:styled-content>) agonists or antagonists, and can modulate both <jats:styled-content style="fixed-case">TLR</jats:styled-content> and nod‐like receptor (<jats:styled-content style="fixed-case">NLR</jats:styled-content>) signalling cascades. Collectively, this diverse group of molecules may represent important therapeutic targets in the prevention and/or treatment of acute lung injury (<jats:styled-content style="fixed-case">ALI</jats:styled-content>) and its more severe form, acute respiratory distress syndrome (<jats:styled-content style="fixed-case">ARDS</jats:styled-content>).</jats:p>
収録刊行物
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- The Journal of Pathology
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The Journal of Pathology 229 (2), 145-156, 2012-12-12
Wiley