In vitro organogenesis in three dimensions: self-organising stem cells
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- Yoshiki Sasai
- Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan
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- Mototsugu Eiraku
- Unit of Four-Dimensional Tissue Analysis, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan
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- Hidetaka Suga
- Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan
書誌事項
- 公開日
- 2012-11-15
- 資源種別
- journal article
- DOI
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- 10.1242/dev.079590
- 公開者
- The Company of Biologists
この論文をさがす
説明
<jats:p>Organ formation during embryogenesis is a complex process that involves various local cell-cell interactions at the molecular and mechanical levels. Despite this complexity, organogenesis can be modelled in vitro. In this article, we focus on two recent examples in which embryonic stem cells can self-organise into three-dimensional structures – the optic cup and the pituitary epithelium; and one case of self-organising adult stem cells – the gut epithelium. We summarise how these approaches have revealed intrinsic programs that drive locally autonomous modes of organogenesis and homeostasis. We also attempt to interpret the results of previous in vivo studies of retinal development in light of the self-organising nature of the retina.</jats:p>
収録刊行物
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- Development
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Development 139 (22), 4111-4121, 2012-11-15
The Company of Biologists
