Pathologically Relevant Mouse Models for Epstein–Barr Virus–Associated B Cell Lymphoma
書誌事項
- 公開日
- 2021-02-24
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3389/fimmu.2021.639844
- 公開者
- Frontiers Media SA
説明
<jats:p>The Epstein–Barr virus (EBV) is endemic in humans and can efficiently transform infected B cells under some circumstances. If an EBV carrier experiences immune suppression, EBV<jats:sup>+</jats:sup> B cells can turn into lymphoblasts and exhibit growth expansion that may cause lymphoproliferative diseases which often develop into lymphoma. Our immune system conducts surveillance for EBV<jats:sup>+</jats:sup> B cells in order to block spontaneous tumor formation. Here, we summarize the EBV products involved in tumorigenesis, EBV-associated lymphomas, and pathologically relevant mouse models. Preclinical mouse models for a range of EBV-associated diseases not only clear the path to new therapeutic approaches but also aid in our understanding of the nature of lymphomagenesis and immune surveillance.</jats:p>
収録刊行物
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- Frontiers in Immunology
-
Frontiers in Immunology 12 2021-02-24
Frontiers Media SA
