Evidence for rapid disappearance of initially expanded HIV-specific CD8<sup>+</sup>T cell clones during primary HIV infection

DOI Web Site 被引用文献2件
  • Giuseppe Pantaleo
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • Hugo Soudeyns
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • James F. Demarest
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • Mauro Vaccarezza
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • Cecilia Graziosi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • Stefania Paolucci
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • MaryBeth Daucher
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • Oren J. Cohen
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • François Denis
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • William E. Biddison
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • Rafick P. Sekaly
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...
  • Anthony S. Fauci
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Laboratory of Immunology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada; Department de Microbiologie et d’Immunologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada; and Department of Microbiology and Immunology, McGill University,...

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<jats:p>Down-regulation of the initial burst of viremia during primary HIV infection is thought to be mediated predominantly by HIV-specific cytotoxic T lymphocytes, and the appearance of this response is associated with major perturbations of the T cell receptor repertoire. Changes in the T cell receptor repertoire of virus-specific cytotoxic T lymphocytes were analyzed in patients with primary infection to understand the failure of the cellular immune response to control viral spread and replication. This analysis demonstrated that a significant number of HIV-specific T cell clones involved in the primary immune response rapidly disappeared. The disappearance was not the result of mutations in the virus epitopes recognized by these clones. Evidence is provided that phenomena such as high-dose tolerance or clonal exhaustion might be involved in the disappearance of these monoclonally expanded HIV-specific cytotoxic T cell clones. These findings should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection.</jats:p>

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