Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole
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- Doug A. Medvetz
- Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA
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- Khadijah M. Hindi
- Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA
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- Matthew J. Panzner
- Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA
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- Andrew J. Ditto
- Olsen Research Center 301D, Department of Biomedical Engineering, The University of Akron, Akron, OH 44325-0302, USA
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- Yang H. Yun
- Olsen Research Center 301D, Department of Biomedical Engineering, The University of Akron, Akron, OH 44325-0302, USA
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- Wiley J. Youngs
- Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA
書誌事項
- 公開日
- 2008-07-01
- 権利情報
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- http://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.1155/2008/384010
- 公開者
- Hindawi Limited
この論文をさがす
説明
<jats:p>A class of Ag(I) N-heterocyclic carbene silver complexes, <jats:bold>1</jats:bold>–<jats:bold>3</jats:bold>, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes <jats:bold>1</jats:bold>–<jats:bold>3</jats:bold> are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows <jats:bold>1</jats:bold> to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.</jats:p>
収録刊行物
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- Metal-Based Drugs
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Metal-Based Drugs 2008 1-7, 2008-07-01
Hindawi Limited