Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive rats.

DOI Web Site 被引用文献2件
  • D Mukherjee
    Department of Heart and Hypertension Research, Cleveland Clinic Foundation, OH 44195-5071.
  • S Sen
    Department of Heart and Hypertension Research, Cleveland Clinic Foundation, OH 44195-5071.

抄録

<jats:p>The myocardium contains collagen matrix that is a major determinant of its architecture, structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I and type III collagens having epimysial, perimysial, and endomysial components. The present study shows the alteration of collagen phenotypes during the evolution of hypertensive hypertrophy. Therapy with captopril, an angiotensin-converting enzyme inhibitor that regresses cardiac hypertrophy, not only reduces the total amount of collagen but reverses the altered distribution of type I and type III collagen. In normotensive rats, captopril did not significantly reduce collagen content or alter the ratio of type I to type III collagen.</jats:p>

収録刊行物

  • Circulation Research

    Circulation Research 67 (6), 1474-1480, 1990-12

    Ovid Technologies (Wolters Kluwer Health)

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ