Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging
-
- Tuba M. Ansary
- Department of Dermatology, Faculty of Medicine, Jichi Medical University, Tochigi 329-0498, Japan
-
- Md. Razib Hossain
- Department of Dermatology, Faculty of Medicine, Jichi Medical University, Tochigi 329-0498, Japan
-
- Koji Kamiya
- Department of Dermatology, Faculty of Medicine, Jichi Medical University, Tochigi 329-0498, Japan
-
- Mayumi Komine
- Department of Dermatology, Faculty of Medicine, Jichi Medical University, Tochigi 329-0498, Japan
-
- Mamitaro Ohtsuki
- Department of Dermatology, Faculty of Medicine, Jichi Medical University, Tochigi 329-0498, Japan
説明
<jats:p>Skin is the largest and most complex organ in the human body comprised of multiple layers with different types of cells. Different kinds of environmental stressors, for example, ultraviolet radiation (UVR), temperature, air pollutants, smoking, and diet, accelerate skin aging by stimulating inflammatory molecules. Skin aging caused by UVR is characterized by loss of elasticity, fine lines, wrinkles, reduced epidermal and dermal components, increased epidermal permeability, delayed wound healing, and approximately 90% of skin aging. These external factors can cause aging through reactive oxygen species (ROS)-mediated inflammation, as well as aged skin is a source of circulatory inflammatory molecules which accelerate skin aging and cause aging-related diseases. This review article focuses on the inflammatory pathways associated with UVR-mediated skin aging.</jats:p>
収録刊行物
-
- International Journal of Molecular Sciences
-
International Journal of Molecular Sciences 22 (8), 3974-, 2021-04-12
MDPI AG
