The Genetics of Parkinson’s Disease and Implications for Clinical Practice

DOI Web Site 2 Citations

Description

<jats:p>The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.</jats:p>

Journal

  • Genes

    Genes 12 (7), 1006-, 2021-06-30

    MDPI AG

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