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- Jacob Oliver Day
- Faculty of Health, University of Plymouth, Plymouth PL4 8AA, UK
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- Stephen Mullin
- Faculty of Health, University of Plymouth, Plymouth PL4 8AA, UK
説明
<jats:p>The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.</jats:p>
収録刊行物
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- Genes
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Genes 12 (7), 1006-, 2021-06-30
MDPI AG
