Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior

  • Kyle A. Lyman
    Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Chicago, IL 60611, USA.
  • Ye Han
    Department of Neurology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA.
  • Chengwen Zhou
    Department of Neurology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA.
  • Isabelle Renteria
    Department of Neurology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA.
  • Gai-Linn Besing
    Department of Neurology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA.
  • Jonathan E. Kurz
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, 225 E. Chicago Ave., Chicago, IL 60611, USA.
  • Dane M. Chetkovich
    Department of Neurology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA.

Abstract

<jats:p>cAMP-mediated effect on HCN channel surface trafficking and mouse behavior depends on activation time scale.</jats:p>

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