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- Nirajan Shrestha
- School of Medical Science Griffith University Southport Qld Australia
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- Simone L. Sleep
- School of Medical Science Griffith University Southport Qld Australia
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- James S.M. Cuffe
- School of Medical Science Griffith University Southport Qld Australia
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- Olivia J. Holland
- School of Medical Science Griffith University Southport Qld Australia
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- Anthony V. Perkins
- School of Medical Science Griffith University Southport Qld Australia
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- Suk Yu Yau
- Department of Rehabilitation Sciences The Hong Kong Polytechnic University Hong Kong Hong Kong
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- Andrew J. McAinch
- Institute for Health and Sport Victoria University Melbourne Vic. Australia
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- Deanne H. Hryciw
- Institute for Health and Sport Victoria University Melbourne Vic. Australia
説明
<jats:title>Abstract</jats:title><jats:p>Maternal nutrition plays a critical role in fetal development and can influence adult onset of disease. Linoleic acid (LA) and alpha‐linolenic acid (ALA) are major omega‐6 (n‐6) and n‐3 polyunsaturated fatty acids (PUFA), respectively, that are essential in our diet. LA and ALA are critical for the development of the fetal neurological and immune systems. However, in recent years, the consumption of n‐6 PUFA has increased gradually worldwide, and elevated n‐6 PUFA consumption may be harmful to human health. Consumption of diets with high levels of n‐6 PUFA before or during pregnancy may have detrimental effects on fetal development and may influence overall health of offspring in adulthood. This review discusses the role of n‐6 PUFA in fetal programming, the importance of a balance between n‐6 and n‐3 PUFAs in the maternal diet, and the need of further animal models and human studies that critically evaluate both n‐6 and n‐3 PUFA contents in diets.</jats:p>
収録刊行物
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- Clinical and Experimental Pharmacology and Physiology
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Clinical and Experimental Pharmacology and Physiology 47 (5), 907-915, 2020-01-28
Wiley
