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- Kotaro Uemura
- Diagnostic Pathology
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- Masato Komatsu
- Diagnostic Pathology
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- Shigeo Hara
- Department of Diagnostic Pathology, Kobe City Medical Center General Hospital
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- Teruya Kawamoto
- Orthopedic Surgery
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- Yuko Bitoh
- Pediatric Surgery
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- Tomoo Itoh
- Diagnostic Pathology
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- Takanori Hirose
- Division of Pathology for Regional Communication, Kobe University Graduate School of Medicine
書誌事項
- 公開日
- 2023-03-06
- 資源種別
- journal article
- DOI
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- 10.1097/pas.0000000000002029
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
この論文をさがす
説明
<jats:p>Angiofibroma of soft tissue (AFST) is a recently described benign fibroblastic neoplasm composed of uniform bland spindle cell proliferation in fibrous and fibromyxoid stroma with prominent thin-walled small branching vessels. A major recurrent genetic abnormality in AFST is t(5;8)(p15;q13), which results in the rearrangement of <jats:italic toggle="yes">AHRR</jats:italic> and <jats:italic toggle="yes">NCOA2</jats:italic>. Owing to a lack of discriminatory IHC markers and potential overlap with other mesenchymal neoplasms, it may be difficult to confirm the diagnosis of AFST in some cases. Triggered by a recent gene expression profile study of AFST, which showed the significant upregulation of AhR/AHRR/ARNT downstream genes (including <jats:italic toggle="yes">CYP1A1</jats:italic>), we used a mouse monoclonal antibody to explore the diagnostic significance of CYP1A1 expression in histologically confirmed AFST cases along with 224 control cases, consisting of 221 neoplastic mimickers and 3 non-neoplastic lesions. We found moderate to strong cytoplasmic expression of CYP1A1 in 13 of 16 AFST cases (sensitivity, 81.3%). In contrast, the vast majority of other examined histologic mimickers exhibited no expression of CYP1A1 (specificity, 97.3%), except for 3 myxofibrosarcomas (3/31), 2 solitary fibrous tumors (2/22), and 2 neurofibroma (1/27). Our results indicate that CYP1A1 immunohistochemistry may aid in the diagnosis of AFST by distinguishing among various kinds of tumors, particularly those harboring prominent vasculature.</jats:p>
収録刊行物
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- American Journal of Surgical Pathology
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American Journal of Surgical Pathology 47 (5), 547-557, 2023-03-06
Ovid Technologies (Wolters Kluwer Health)
