Branched-chain amino acids enhance cyst development in autosomal dominant polycystic kidney disease
書誌事項
- 公開日
- 2017-08
- 資源種別
- journal article
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- http://www.elsevier.com/open-access/userlicense/1.0/
- DOI
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- 10.1016/j.kint.2017.01.021
- 公開者
- Elsevier BV
この論文をさがす
説明
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive development of kidney and liver cysts. The mammalian target of rapamycin (mTOR) cascade is one of the important pathways regulating cyst growth in ADPKD. Branched-chain amino acids (BCAAs), including leucine, play a crucial role to activate mTOR pathway. Therefore, we administered BCAA dissolved in the drinking water to Pkd1
収録刊行物
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- Kidney International
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Kidney International 92 (2), 377-387, 2017-08
Elsevier BV
