African origin of the malaria parasite Plasmodium vivax

DOI PDF Web Site PubMed 被引用文献7件 参考文献54件 オープンアクセス

書誌事項

公開日
2014-02-21
資源種別
journal article
権利情報
  • https://www.springernature.com/gp/researchers/text-and-data-mining
  • https://www.springernature.com/gp/researchers/text-and-data-mining
DOI
  • 10.1038/ncomms4346
公開者
Springer Science and Business Media LLC

説明

Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. vivax is believed to have originated in Asia. Here we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax. Sequence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. These findings indicate that human P. vivax is of African origin and likely selected for the Duffy-negative mutation. All extant human P. vivax parasites are derived from a single ancestor that escaped out of Africa.

収録刊行物

  • Nature Communications

    Nature Communications 5 (1), 3346-, 2014-02-21

    Springer Science and Business Media LLC

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