Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

DOI Web Site PubMed 被引用文献50件 参考文献41件 オープンアクセス
  • Kazuhiro Kawamura
    Department of Obstetrics and Gynecology and
  • Yuan Cheng
    Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317;
  • Nao Suzuki
    Department of Obstetrics and Gynecology and
  • Masashi Deguchi
    Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317;
  • Yorino Sato
    Department of Obstetrics and Gynecology and
  • Seido Takae
    Department of Obstetrics and Gynecology and
  • Chi-hong Ho
    Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317;
  • Nanami Kawamura
    Department of Advanced Reproductive Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan;
  • Midori Tamura
    Department of Obstetrics and Gynecology and
  • Shu Hashimoto
    IVF Namba Clinic, Osaka, Osaka 550-0015, Japan; and
  • Yodo Sugishita
    Department of Obstetrics and Gynecology and
  • Yoshiharu Morimoto
    IVF Namba Clinic, Osaka, Osaka 550-0015, Japan; and
  • Yoshihiko Hosoi
    Graduate School of Biology-Oriented Science and Technology, Kinki University, Wakayama, Wakayama 649-6493, Japan
  • Nobuhito Yoshioka
    Department of Obstetrics and Gynecology and
  • Bunpei Ishizuka
    Department of Advanced Reproductive Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa 216-8511, Japan;
  • Aaron J. Hsueh
    Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317;

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<jats:title>Significance</jats:title> <jats:p>Human ovaries hold follicles containing oocytes. When follicles mature, they release eggs for fertilization. Patients with primary ovarian insufficiency develop menopausal symptoms at less than 40 y of age. They have few remaining follicles and their only chance for bearing a baby is through egg donation. Kawamura et al. demonstrated that Hippo and Akt signaling pathways regulate follicle growth. Using an in vitro activation approach, they first removed ovaries from infertile patients, followed by fragmentation to disrupt Hippo signaling and drug treatment to stimulate Akt signaling. After grafting ovarian tissues back to patients, they found rapid follicle growth in some patients and successfully retrieved mature eggs. After in vitro fertilization and embryo transfer, a live birth is now reported.</jats:p>

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