Inflammatory myofibroblastic tumor with RANBP2 and ALKgene rearrangement: a report of two cases and literature review

DOI PDF PDF Web Site PubMed 被引用文献2件 参考文献22件 オープンアクセス

書誌事項

公開日
2013-09-13
資源種別
journal article
権利情報
  • http://creativecommons.org/licenses/by/2.0
DOI
  • 10.1186/1746-1596-8-147
公開者
Springer Science and Business Media LLC

説明

<jats:title>Abstract</jats:title> <jats:p>Inflammatory myofibroblastic tumors (IMTs) are categorized as intermediate biologic neoplasms, whereas IMTs with genetic features of ran-binding protein 2 (<jats:italic>RANBP2</jats:italic>) and anaplastic lymphoma kinase (<jats:italic>ALK</jats:italic>) rearrangement (IMT-RAs) are possibly related to a more aggressive clinical course. However, fewer than 10 cases of IMT-RA have been reported to date. Herein, we present 2 new cases of IMT-RA in which both tumors recurred quickly after primary surgery; one patient died 3 months later from the disease, and the other patient has been living with the disease for 12 months. IMT-RAs are characterized by noncohesive epithelioid and rounded tumoral cell morphology, commonly derived from pelvic and peritoneal cavities, and frequently show larger tumor sizes. The relation between the clinicopathologic features and poor prognosis of IMT-RA is discussed.</jats:p> <jats:p> <jats:bold>Virtual slides</jats:bold> </jats:p> <jats:p>The virtual slide(s) for this article can be found here: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.diagnosticpathology.diagnomx.eu/vs/3314123381007714" ext-link-type="uri">http://www.diagnosticpathology.diagnomx.eu/vs/3314123381007714</jats:ext-link> </jats:p>

収録刊行物

  • Diagnostic Pathology

    Diagnostic Pathology 8 (1), 147-, 2013-09-13

    Springer Science and Business Media LLC

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