Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation
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- Marco Prinz
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg, D-79106 Freiburg, Germany;
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- Takahiro Masuda
- Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 812-8582 Fukuoka, Japan;
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- Michael A. Wheeler
- Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;,
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- Francisco J. Quintana
- Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;,
抄録
<jats:p> The immune system of the central nervous system (CNS) consists primarily of innate immune cells. These are highly specialized macrophages found either in the parenchyma, called microglia, or at the CNS interfaces, such as leptomeningeal, perivascular, and choroid plexus macrophages. While they were primarily thought of as phagocytes, their function extends well beyond simple removal of cell debris during development and diseases. Brain-resident innate immune cells were found to be plastic, long-lived, and host to an outstanding number of risk genes for multiple pathologies. As a result, they are now considered the most suitable targets for modulating CNS diseases. Additionally, recent single-cell technologies enhanced our molecular understanding of their origins, fates, interactomes, and functional cell statesduring health and perturbation. Here, we review the current state of our understanding and challenges of the myeloid cell biology in the CNS and treatment options for related diseases. </jats:p>
収録刊行物
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- Annual Review of Immunology
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Annual Review of Immunology 39 (1), 251-277, 2021-04-26
Annual Reviews
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詳細情報 詳細情報について
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- CRID
- 1360572092367883776
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- ISSN
- 15453278
- 07320582
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- データソース種別
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- Crossref
- KAKEN