Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence
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- Shian‐Ren Lin
- Department of Life Science and Institute of Biotechnology National Dong Hwa University Hualien Taiwan
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- Chia‐Hsiang Chang
- Department of Life Science and Institute of Biotechnology National Dong Hwa University Hualien Taiwan
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- Che‐Fang Hsu
- Department of Life Science and Institute of Biotechnology National Dong Hwa University Hualien Taiwan
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- May‐Jwan Tsai
- Neural Regeneration Laboratory, Neurological Institute Taipei Veterans General Hospital Taipei City Taiwan
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- Henrich Cheng
- Neural Regeneration Laboratory, Neurological Institute Taipei Veterans General Hospital Taipei City Taiwan
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- Max K. Leong
- Department of Chemistry National Dong Hwa University Hualien Taiwan
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- Ping‐Jyun Sung
- Graduate Institute of Marine Biotechnology National Dong Hwa University Pingtung Taiwan
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- Jian‐Chyi Chen
- Department of Biotechnology Southern Taiwan University of Science and Technology Tainan City Taiwan
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- Ching‐Feng Weng
- Graduate Institute of Marine Biotechnology National Dong Hwa University Pingtung Taiwan
説明
<jats:sec><jats:label /><jats:p>Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural‐based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as <jats:styled-content style="fixed-case"><jats:italic>Solanum nigrum</jats:italic></jats:styled-content> and <jats:italic>Claviceps purpurea</jats:italic> and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb–drug interactions, should be carefully considered.</jats:p></jats:sec><jats:sec><jats:title>Linked Articles</jats:title><jats:p>This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc">http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc</jats:ext-link></jats:p></jats:sec>
収録刊行物
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- British Journal of Pharmacology
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British Journal of Pharmacology 177 (6), 1409-1423, 2019-11-27
Wiley