Mixed-effects association of single cells identifies an expanded effector CD4<sup>+</sup>T cell subset in rheumatoid arthritis
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- Chamith Y. Fonseka
- Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Deepak A. Rao
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Nikola C. Teslovich
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Ilya Korsunsky
- Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Susan K. Hannes
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Kamil Slowikowski
- Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Michael F. Gurish
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Laura T. Donlin
- Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.
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- James A. Lederer
- Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Michael E. Weinblatt
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Elena M. Massarotti
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Jonathan S. Coblyn
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Simon M. Helfgott
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Derrick J. Todd
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Vivian P. Bykerk
- Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA.
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- Elizabeth W. Karlson
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Joerg Ermann
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Yvonne C. Lee
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Michael B. Brenner
- Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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- Soumya Raychaudhuri
- Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
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説明
<jats:p>Mixed-effects regression of single-cell data accounts for confounding variation and reveals an expanded CD4<jats:sup>+</jats:sup>T cell population in rheumatoid arthritis.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 10 (463), eaaq0305-, 2018-10-17
American Association for the Advancement of Science (AAAS)