DNA-binding specificities of plant transcription factors and their potential to define target genes

DOI Web Site 被引用文献14件
  • José M. Franco-Zorrilla
    Genomics Unit and
  • Irene López-Vidriero
    Genomics Unit and
  • José L. Carrasco
    Instituto de Biología Molecular y Celular de Plantas, Universidad Politécnica de Valencia-Consejo Superior de Investigaciones Científicas, 46022 Valencia, Spain
  • Marta Godoy
    Genomics Unit and
  • Pablo Vera
    Instituto de Biología Molecular y Celular de Plantas, Universidad Politécnica de Valencia-Consejo Superior de Investigaciones Científicas, 46022 Valencia, Spain
  • Roberto Solano
    Department of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB)-Consejo Superior de Investigaciones Científicas (CSIC), Darwin 3, 28049 Madrid, Spain; and

書誌事項

公開日
2014-01-29
DOI
  • 10.1073/pnas.1316278111
公開者
Proceedings of the National Academy of Sciences

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説明

<jats:title>Significance</jats:title> <jats:p> We described the high-throughput identification of DNA-binding specificities of 63 plant transcription factors (TFs) and their relevance as <jats:italic>cis-</jats:italic> regulatory elements in vivo. Almost half of the TFs recognized secondary motifs partially or completely differing from their corresponding primary ones. Analysis of coregulated genes, transcriptomic data, and chromatin hypersensitive regions revealed the biological relevance of more than 80% of the binding sites identified. Our combined analysis allows the prediction of the function of a particular TF as activator or repressor through a particular DNA sequence. The data support the correlation between <jats:italic>cis-</jats:italic> regulatory elements in vivo and the sequence determined in vitro. Moreover, it provides a framework to explore regulatory networks in plants and contributes to decipher the transcriptional regulatory code. </jats:p>

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