Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure
書誌事項
- 公開日
- 2021-03-29
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3389/fcvm.2021.631807
- 公開者
- Frontiers Media SA
説明
<jats:p><jats:bold>Aims:</jats:bold> We aimed to assess the associations of CAVI with exercise capacity in heart failure (HF) patients. In addition, we further examined their prognosis.</jats:p><jats:p><jats:bold>Methods:</jats:bold> We collected the clinical data of 223 patients who had been hospitalized for decompensated HF and had undergone both CAVI and cardiopulmonary exercise testing.</jats:p><jats:p><jats:bold>Results:</jats:bold> For the prediction of an impaired peak oxygen uptake (VO<jats:sub>2</jats:sub>) of < 14 mL/kg/min, receiver-operating characteristic curve demonstrated that the cutoff value of CAVI was 8.9. In the multivariate logistic regression analysis for predicting impaired peak VO<jats:sub>2</jats:sub>, high CAVI was found to be an independent factor (odds ratio 2.343, <jats:italic>P</jats:italic> = 0.045). We divided these patients based on CAVI: the low-CAVI group (CAVI < 8.9, <jats:italic>n</jats:italic> = 145) and the high-CAVI group (CAVI ≥ 8.9, <jats:italic>n</jats:italic> = 78). Patient characteristics and post-discharge cardiac events were compared between the two groups. The high-CAVI group was older (69.0 vs. 58.0 years old, <jats:italic>P</jats:italic> < 0.001) and had lower body mass index (23.0 vs. 24.1 kg/m<jats:sup>2</jats:sup>, <jats:italic>P</jats:italic> = 0.013). During the post-discharge follow-up period of median 1,623 days, 58 cardiac events occurred. The Kaplan–Meier analysis demonstrated that the cardiac event rate was higher in the high-CAVI group than in the low-CAVI group (log–rank <jats:italic>P</jats:italic> = 0.004). The multivariate Cox proportional hazard analysis revealed that high CAVI was an independent predictor of cardiac events (hazard ratio 1.845, <jats:italic>P</jats:italic> = 0.035).</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> High CAVI is independently associated with impaired exercise capacity and a high cardiac event rate in HF patients.</jats:p>
収録刊行物
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- Frontiers in Cardiovascular Medicine
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Frontiers in Cardiovascular Medicine 8 2021-03-29
Frontiers Media SA
