CD3 bispecific antibody–induced cytokine release is dispensable for cytotoxic T cell activity
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- Ji Li
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Robert Piskol
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Ryan Ybarra
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Ying-Jiun J. Chen
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Jason Li
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Dionysos Slaga
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Maria Hristopoulos
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Robyn Clark
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Zora Modrusan
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Klara Totpal
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Melissa R. Junttila
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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- Teemu T. Junttila
- Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
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説明
<jats:p>Cytokine release induced by anti-HER2/CD3 is mediated by TNF-α and can be suppressed by blocking TNF-α, IL-6, or IL-1 without affecting efficacy.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 11 (508), 2019-09-04
American Association for the Advancement of Science (AAAS)
