Life-Sparing Effect of Human Cord Blood-Mesenchymal Stem Cells in Experimental Acute Kidney Injury

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  • Marina Morigi
    “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
  • Cinzia Rota
    “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
  • Tiziana Montemurro
    Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
  • Elisa Montelatici
    Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
  • Viviana Lo Cicero
    Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
  • Barbara Imberti
    “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
  • Mauro Abbate
    “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
  • Carla Zoja
    “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
  • Paola Cassis
    “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
  • Lorena Longaretti
    “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
  • Paolo Rebulla
    Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
  • Martino Introna
    Laboratory of Cell Therapy “G. Lanzani,” Ospedali Riuniti di Bergamo, Bergamo, ItalyUnit of Hematology and Unit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Bergamo, Italy
  • Chiara Capelli
    Laboratory of Cell Therapy “G. Lanzani,” Ospedali Riuniti di Bergamo, Bergamo, ItalyUnit of Hematology and Unit of Nephrology and Dialysis, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Bergamo, Italy
  • Ariela Benigni
    “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
  • Giuseppe Remuzzi
    “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy
  • Lorenza Lazzari
    Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy

抄録

<jats:title>Abstract</jats:title><jats:p>In search for new sources of mesenchymal stem cells (MSCs) for renal repair in acute kidney injury (AKI), we investigated the potential of human cord blood (CB)-MSCs to cure mice with AKI. Infusion of CB-MSCs in immunodeficient mice with cisplatin-induced AKI ameliorated both renal function and tubular cell injury, and prolonged survival. Transplanted CB-MSCs localized in peritubular areas, limited capillary alterations and neutrophil infiltration. Apoptosis reduced and tubular cell proliferation increased by virtue of stem cell capacity to produce growth factors. The reno-protective effect of CB-MSCs was further confirmed by their ability to inhibit oxidative damage and to induce the prosurvival factor Akt in tubular cells. The evidence that CB-MSCs in vitro increased the production of growth factors and inhibited IL-1β and TNFα synthesis when cocultured with damaged proximal tubular cells indicates a regenerative and anti-inflammatory action of stem cell treatment. Altogether these results highlight the potential of human CB-MSCs as future cell therapy for testing in human AKI.</jats:p>

収録刊行物

  • Stem Cells

    Stem Cells 28 (3), 513-522, 2010-01-04

    Oxford University Press (OUP)

被引用文献 (3)*注記

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