Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity
書誌事項
- 公開日
- 2022-11
- 資源種別
- journal article
- 権利情報
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- http://creativecommons.org/licenses/by-nc-nd/4.0/
- DOI
-
- 10.1016/j.isci.2022.105412
- 公開者
- Elsevier BV
この論文をさがす
説明
Live-attenuated vaccines are generally highly effective. Here, we aimed to develop one against SARS-CoV-2, based on the identification of three types of temperature-sensitive (TS) strains with mutations in nonstructural proteins (nsp), impaired proliferation at 37°C-39°C, and the capacity to induce protective immunity in Syrian hamsters. To develop a live-attenuated vaccine, we generated a virus that combined all these TS-associated mutations (rTS-all), which showed a robust TS phenotype
収録刊行物
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- iScience
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iScience 25 (11), 105412-, 2022-11
Elsevier BV
