KaKs_Calculator 3.0: Calculating Selective Pressure on Coding and Non-Coding Sequences
-
- Zhang Zhang
- National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing, 100101 , China
書誌事項
- 公開日
- 2022-01-03
- 権利情報
-
- https://creativecommons.org/licenses/by/4.0/
- https://www.elsevier.com/tdm/userlicense/1.0/
- http://creativecommons.org/licenses/by/4.0/
- DOI
-
- 10.1016/j.gpb.2021.12.002
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>KaKs_Calculator 3.0 is an updated toolkit that is capable of calculating selective pressure on both coding and non-coding sequences. Similar to the nonsynonymous/synonymous substitution rate ratio for coding sequences, selection on non-coding sequences can be quantified as the ratio of non-coding nucleotide substitution rate to synonymous substitution rate of adjacent coding sequences. As testified on empirical data, KaKs_Calculator 3.0 shows effectiveness to detect the strength and mode of selection operated on molecular sequences, accordingly demonstrating its great potential to achieve genome-wide scan of natural selection on diverse sequences and identification of potentially functional elements at a whole-genome scale. The package of KaKs_Calculator 3.0 is freely available for academic use only at https://ngdc.cncb.ac.cn/biocode/tools/BT000001.</jats:p>
収録刊行物
-
- Genomics, Proteomics & Bioinformatics
-
Genomics, Proteomics & Bioinformatics 20 (3), 536-540, 2022-01-03
Oxford University Press (OUP)
