Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy
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- Tareq Saleh
- 1Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
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- Liliya Tyutyunyk-Massey
- 2Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, Virginia.
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- David A. Gewirtz
- 2Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, Virginia.
書誌事項
- 公開日
- 2019-03-15
- DOI
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- 10.1158/0008-5472.can-18-3437
- 公開者
- American Association for Cancer Research (AACR)
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説明
<jats:title>Abstract</jats:title> <jats:p>Senescence, a durable form of growth arrest, represents a primary response to numerous anticancer therapies. Although the paradigm that senescence is “irreversible” has largely withstood the findings of tumor cell recovery from what has been termed “pseudo-senescence” or “senescence-like arrest,” a review of the literature suggests that therapy-induced senescence in tumor cells is not obligatorily a permanent cell fate. Consequently, we propose that senescence represents one avenue whereby tumor cells evade the direct cytotoxic impact of therapy, thereby allowing for prolonged survival in a dormant state, with the potential to recover self-renewal capacity and contribute to disease recurrence.</jats:p>
収録刊行物
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- Cancer Research
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Cancer Research 79 (6), 1044-1046, 2019-03-15
American Association for Cancer Research (AACR)
