Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation
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- Liping Zuo
- School of Life Science
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- Jingjing Ding
- School of Life Science
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- Changkun Li
- Shimadzu (China) Co., Ltd
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- Feng Lin
- Peking-Tsinghua Center for Life Sciences
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- Peng R. Chen
- Peking-Tsinghua Center for Life Sciences
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- Peilin Wang
- School of Life Science
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- Guihong Lu
- School of Life Science
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- Jinfeng Zhang
- School of Life Science
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- Li-Li Huang
- School of Life Science
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- Hai-Yan Xie
- School of Life Science
抄録
<p>Spatiotemporally controlled activation: Dox-TCO loaded low pH-sensitive nanovehicles and Tz-containing MMP-2-sensitive nanocarriers simultaneously dissociated in tumor microenvironment, with Dox locally liberated through IEDDA biorthogonal reaction.</p>
収録刊行物
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- Chemical Science
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Chemical Science 11 (8), 2155-2160, 2020
Royal Society of Chemistry (RSC)