Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways
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- Hiroki Takahashi
- Division of Molecular Physiology and Metabolism Tohoku University Graduate School of Medicine Sendai Japan
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- Ryo Ito
- Division of Molecular Physiology and Metabolism Tohoku University Graduate School of Medicine Sendai Japan
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- Yoshihiro Matsumura
- Division of Molecular Physiology and Metabolism Tohoku University Graduate School of Medicine Sendai Japan
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- Juro Sakai
- Division of Molecular Physiology and Metabolism Tohoku University Graduate School of Medicine Sendai Japan
書誌事項
- 公開日
- 2023-11-27
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by-nc-nd/4.0/
- DOI
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- 10.1002/bies.202300084
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Organisms must adapt to environmental stresses to ensure their survival and prosperity. Different types of stresses, including thermal, mechanical, and hypoxic stresses, can alter the cellular state that accompanies changes in gene expression but not the cellular identity determined by a chromatin state that remains stable throughout life. Some tissues, such as adipose tissue, demonstrate remarkable plasticity and adaptability in response to environmental cues, enabling reversible cellular identity changes; however, the mechanisms underlying these changes are not well understood. We hypothesized that positive and/or negative “Integrators” sense environmental cues and coordinate the epigenetic and transcriptional pathways required for changes in cellular identity. Adverse environmental factors such as pollution disrupt the coordinated control contributing to disease development. Further research based on this hypothesis will reveal how organisms adapt to fluctuating environmental conditions, such as temperature, extracellular matrix stiffness, oxygen, cytokines, and hormonal cues by changing their cellular identities.</jats:p>
収録刊行物
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- BioEssays
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BioEssays 46 (2), 2023-11-27
Wiley
