Remdesivir Resistance in Transplant Recipients With Persistent Coronavirus Disease 2019
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- John I Hogan
- Department of Medicine, NYU Long Island School of Medicine , Mineola, New York , USA
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- Ralf Duerr
- Department of Microbiology, NYU Grossman School of Medicine , New York, New York , USA
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- Dacia Dimartino
- Genome Technology Center, NYU Langone Health , New York, New York , USA
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- Christian Marier
- Genome Technology Center, NYU Langone Health , New York, New York , USA
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- Sarah E Hochman
- Department of Medicine, NYU Grossman School of Medicine , New York, New York , USA
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- Sapna Mehta
- Department of Medicine, NYU Grossman School of Medicine , New York, New York , USA
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- Guiqing Wang
- Department of Medicine, NYU Grossman School of Medicine , New York, New York , USA
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- Adriana Heguy
- Genome Technology Center, NYU Langone Health , New York, New York , USA
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説明
<jats:title>Abstract</jats:title> <jats:p>New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.</jats:p>
収録刊行物
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- Clinical Infectious Diseases
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Clinical Infectious Diseases 76 (2), 342-345, 2022-09-26
Oxford University Press (OUP)
