Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys

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  • Takamichi Tohyama
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan;
  • Masaharu Kinoshita
    Department of Physiology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan;
  • Kenta Kobayashi
    Section of Viral Vector Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan;
  • Kaoru Isa
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan;
  • Dai Watanabe
    Department of Molecular and System Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan;
  • Kazuto Kobayashi
    Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan;
  • Meigen Liu
    Department of Rehabilitation Medicine, Graduate School of Medicine, Keio University, Tokyo 160-8582, Japan;
  • Tadashi Isa
    Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan;

抄録

<jats:title>Significance</jats:title> <jats:p>There are different views about the targets of regenerative therapies to induce functional recovery in patients with motor paralysis following brain and spinal cord injury: whether we should aim at repairing the injured corticospinal tract or at facilitating compensation by other descending motor pathways. To help answer this question, we used double viral vectors to reversibly and selectively block the propriospinal neurons (PNs), one of the major intercalated neurons mediating cortical commands to motoneurons, in monkeys with partial spinal cord injury. We demonstrated causal roles of the PN-mediated pathway in promoting recovery of hand dexterity after the lesion. Thus, targeting the PNs might lead to developing effective treatment to facilitate recovery after spinal cord injury.</jats:p>

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