Translational research on influenza virus infection using a nonhuman primate model
-
- Yasushi Itoh
- Department of Pathology Shiga University of Medical Science Otsu Shiga Japan
書誌事項
- 公開日
- 2016-01-26
- 資源種別
- journal article
- 権利情報
-
- http://onlinelibrary.wiley.com/termsAndConditions#am
- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
-
- 10.1111/pin.12385
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Influenza virus infection is a seasonal infectious disease for humans, whereas it is also a zoonosis that is originally transmitted from animals to humans. Therefore, several animal models are used in research on influenza virus infection. We have used a nonhuman primate (<jats:styled-content style="fixed-case">NHP</jats:styled-content>) model to extrapolate pathogenicity of various influenza viruses and efficacy of vaccines and antiviral drugs against the influenza viruses in humans. <jats:styled-content style="fixed-case">NHP</jats:styled-content>s have genes, anatomical structure, and immune responses similar to those of humans as compared to other animal models. Using an <jats:styled-content style="fixed-case">NHP</jats:styled-content> model, we revealed that the pandemic 2009 influenza <jats:styled-content style="fixed-case">A</jats:styled-content> virus caused viral pneumonia as reported in human patients. Thus, it is thought that <jats:styled-content style="fixed-case">NHP</jats:styled-content> models can be used to predict replication of emerging viruses in humans. We also examined the pathogenicity of highly pathogenic avian influenza viruses and evaluated a new therapeutic antibody in macaques under an immunocompromised condition. <jats:styled-content style="fixed-case">NHP</jats:styled-content> models have provided promising results in research on other infectious diseases including <jats:styled-content style="fixed-case">E</jats:styled-content>bola virus and human/simian immunodeficiency virus infections. Thus, <jats:styled-content style="fixed-case">NHP</jats:styled-content>s are important in biomedical research for determining the pathogenesis and for development of treatments, especially when clinical trials are difficult. We summarize the characteristics and advantages of research using <jats:styled-content style="fixed-case">NHP</jats:styled-content> models in this review.</jats:p>
収録刊行物
-
- Pathology International
-
Pathology International 66 (3), 132-141, 2016-01-26
Wiley
