Antimelanogenic Activity of Ocotillol‐Type Saponins from <i>Panax vietnamensis</i>
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- Hien Minh Nguyen
- Faculty of Pharmacy Ton Duc Thang University Ho Chi Minh City 700000 Vietnam
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- Huy Truong Nguyen
- Faculty of Pharmacy Ton Duc Thang University Ho Chi Minh City 700000 Vietnam
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- Nwet Win
- Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
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- Chin Piow Wong
- Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
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- Kim Long Vu Huynh
- Faculty of Pharmacy Ton Duc Thang University Ho Chi Minh City 700000 Vietnam
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- Nhat Nam Hoang
- Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
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- Kiep Minh Do
- Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
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- Hoai Thi Nguyen
- Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University 49000 Vietnam
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- Duc Viet Ho
- Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University 49000 Vietnam
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- Minh Duc Nguyen
- Faculty of Pharmacy Ton Duc Thang University Ho Chi Minh City 700000 Vietnam
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- Hiroyuki Morita
- Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
書誌事項
- 公開日
- 2020-04-15
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/cbdv.202000037
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The ocotillol (OCT)‐type saponins have been known as a tetracyclic triterpenoid, possessing five‐ or six‐membered epoxy ring in the side chain. Interestingly, this type saponin was mostly found in <jats:italic>Panax vietnamensis</jats:italic> <jats:sc>Ha</jats:sc> et <jats:sc>Grushv</jats:sc>., Araliaceae (VG), hence making VG unique from the other <jats:italic>Panax</jats:italic> spp. Five OCT‐type saponins, majonoside R2, vina‐ginsenoside R2, majonoside R1, pseudoginsenoside RT4, vina‐ginsenoside R11, together with three protopanaxadiol (PPD)‐type saponins and four protopanaxatriol (PPT)‐type saponins from VG were evaluated for their antimelanogenic activity. All of isolates were found to be active. More importantly, the five OCT‐type saponins inhibited melanin production in B16‐F10 mouse melanoma cells, without showing any cytotoxicity. Besides ginsenoside Rd and ginsenoside Rg3 in PPD and notoginsenoside R1 in PPT‐type saponins, majonoside R2 was the most potent melanogenesis inhibitory activity in OCT‐type saponins. In this article, we highlighted antimelanogenic activity of OCT‐type saponins and potential structure–activity relationship (SAR) of ginsenosides. Our results suggested that OCT‐type saponins could be used as a depigmentation agent.</jats:p>
収録刊行物
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- Chemistry & Biodiversity
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Chemistry & Biodiversity 17 (5), 2020-04-15
Wiley
