Total synthesis of biologically active alkaloids using transition metals

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  • Ronny Forke
    1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
  • Konstanze K. Gruner
    1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
  • Kerstin E. Knott
    1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
  • Stefan Auschill
    1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
  • Sameer Agarwal
    1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
  • René Martin
    1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
  • Markus Böhl
    2Institute of Zoology, Technical University of Dresden, Zellescher Weg 20b, 01217 Dresden, Germany
  • Sabine Richter
    2Institute of Zoology, Technical University of Dresden, Zellescher Weg 20b, 01217 Dresden, Germany
  • Georgios Tsiavaliaris
    3Institute for Biophysical Chemistry, Hannover Medical School, 30623 Hannover, Germany
  • Roman Fedorov
    3Institute for Biophysical Chemistry, Hannover Medical School, 30623 Hannover, Germany
  • Dietmar J. Manstein
    3Institute for Biophysical Chemistry, Hannover Medical School, 30623 Hannover, Germany
  • Herwig O. Gutzeit
    2Institute of Zoology, Technical University of Dresden, Zellescher Weg 20b, 01217 Dresden, Germany
  • Hans-Joachim Knölker
    1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany

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<jats:p>We have developed efficient synthetic routes to heterocyclic ring systems using transition metals (palladium, iron, and silver). Recent applications of this chemistry to the total synthesis of biologically active alkaloids include carbazole alkaloids (pityriazole, euchrestifoline, the antiostatins), crispine A, pentabromo- and pentachloropseudilin. The two latter alkaloids represent a novel class of myosin ATPase inhibitors that led to the discovery of a new allosteric binding site of the protein.</jats:p>

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