Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2′-C,4′-C-ethyleneoxy-bridged thymidine derivatives
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- Takashi Osawa
- Faculty of Pharmaceutical Sciences
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- Motoki Sawamura
- Graduate School of Pharmaceutical Sciences
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- Fumito Wada
- Graduate School of Pharmaceutical Sciences
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- Tsuyoshi Yamamoto
- Graduate School of Pharmaceutical Sciences
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- Satoshi Obika
- Graduate School of Pharmaceutical Sciences
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- Yoshiyuki Hari
- Faculty of Pharmaceutical Sciences
抄録
<p>Three new EoDNAs were developed, and they and our previously developed methylene-EoDNAs could represent promising candidates for antisense technology.</p>
収録刊行物
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- Organic & Biomolecular Chemistry
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Organic & Biomolecular Chemistry 15 (18), 3955-3963, 2017
Royal Society of Chemistry (RSC)